Tendulkar cleveland clinic

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services Policy. In a study published earlier this year in the Journal of Clinical Oncology , a research team led by Dr. Tendulkar found that patients in the same dataset as used in the current research who were treated with early SRT were more likely to remain free from biochemical failure and less likely to develop distant metastases.

The present analysis included patients followed for a median of 5. Tendulkar says. But in our study, PSA was a significant predictor of mortality, while some tumor-related factors such as extraprostatic extension and surgical margins were not significant in mortality outcomes upon multivariate analysis.

According to the analysis, overall PCSM rates at 5 and 10 years were 3 percent and 6 percent, respectively. Other factors besides higher PSA levels that contributed to increased PCSM were higher Gleason score, seminal vesicle invasion and year of SRT since more recent treatment dates may preclude sufficient follow-up duration to observe prostate cancer-related deaths.

Optimal postoperative management of men with prostate cancer remains an area of ongoing research. It was created by Andrew J. It demonstrated that an increasing serum prostate-specific antigen PSA level was the initial sign of recurrent prostate cancer among patients treated with radical prostatectomy RP. SRT might eradicate locally recurrent cancer, but studies to distinguish local from systemic recurrence lacked sensitivity and specificity, Dr.

Stephenson noted in The original nomogram predicted the probability of cancer control at six years after SRT for PSA-defined recurrence by evaluating markers such as cancer stage, tumor grade and PSA level. Randomized trials published since the original nomogram was created have demonstrated the benefit of early SRT in high-risk patients. The study was a multi-institutional collaborative effort including more than 2, patients from 10 institutions.

Tendulkar says. The retrospective cohort study examined 2, patients with a median follow-up of 5 years from the end of radiation. Early SRT was associated with improved freedom from biochemical failure and freedom from distant metastases. The updated nomogram is designed to better estimate individual patient outcomes after SRT.

Once the study is published, the nomogram will be made available online at no charge. Were findings a surprise? This nomogram provides a more refined predictive tool than previously available.

The next steps, says Dr. Tendulkar, will include conducting subset analyses to learn more about which patients need what kind of treatment.